Protein Details: Aquaporin TIP2-1

Protein ID

ICDB_Pro_0941

Protein Name

Aquaporin TIP2-1

Gene Name

TIP2-1; At3g16240; MYA6.10

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

250 amino acids

AlphaFoldDB

AF-Q41951-F1-model_v4.pdb

Function

Aquaporin required to facilitate the transport of water from the vacuolar compartment to the cytoplasm. Does not promote glycerol permeability. Its function is impaired by Hg(2+). Transports urea in yeast cells and Xenopus laevis oocytes in a pH-independent manner. Transports methylammonium or ammonium in yeast cells and Xenopus laevis oocytes; preferentially at high medium pH. May participate in vacuolar compartmentation and detoxification of ammonium.

Sequence

MAGVAFGSFDDSFSLASLRAYLAEFISTLLFVFAGVGSAIAYAKLTSDAALDTPGLVAIAVCHGFALFVAVAIGANISGGHVNPAVTFGLAVGGQITVITGVFYWIAQLLGSTAACFLLKYVTGGLAVPTHSVAAGLGSIEGVVMEIIITFALVYTVYATAADPKKGSLGTIAPLAIGLIVGANILAAGPFSGGSMNPARSFGPAVAAGDFSGHWVYWVGPLIGGGLAGLIYGNVFMGSSEHVPLASADF

PDB Structures

5I32

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Strongly expressed in shoot; rosette; bolt and flowers; Also expressed in roots; flower buds and above ground.

DOI ID

10.1105/tpc.8.4.587; 10.1093/dnares/7.2.131; 10.1111/tpj.13415; 10.1126/science.1088305; 10.1046/j.1365-313x.1993.04061051.x; 10.1046/j.1365-313x.1996.09010101.x; 10.1073/pnas.97.7.3718; 10.1186/gb-2001-3-1-research0001; 10.1104/pp.103.027409; 10.1104/pp.104.051268; 10.1099/vir.0.82252-0; 10.1074/mcp.m600250-mcp200; 10.1074/mcp.m111.015131

RefSeq

NP_188245.1